Low magnesium levels usually don't cause any symptoms, but chronically low levels may increase the risk of high blood pressure, heart disease, type 2 diabetes, and osteoporosis. An excess of magnesium can cause loose stools, and for most people, that's more than 200 mg a day. Some people can tolerate more than 500 mg of supplemental magnesium without any problems. The recommended dose of Magnesium L-Threonate is 144 mg of elemental magnesium (pure) daily, given as three capsules of Mag Threonate.
You can have two in the morning and one in the evening. A common side effect of taking magnesium is watery stools; however, this usually occurs when magnesium is taken in doses greater than 1000 mg. The best thing about magnesium l-threonate is that this form has less effect on bowel movements than most forms of magnesium and the typical dose is much lower, 144 mg. It is recommended to take magnesium L-threonate in doses of 1,500 to 2,000 mg per day, divided into different periods.
Older men can increase their dose to 420 mg a day and women in that age group should consume 360 mg of magnesium L-threonate every day for best results. While it can generally increase magnesium levels throughout the body, the effects could be even stronger in the brain with this form of magnesium. There is evidence that magnesium l-threonate may increase brain-derived neurotrophic factor (BDNF), a protein that stimulates the formation of new brain cells. Magnesium L-threonate is available in capsule and powder form, allowing you to take it with you wherever you go.
Studies have found that magnesium L-threonate suppresses IL-1β in glial cells delineated within signaling pathways. The correct dosage of magnesium L-threonate or drug depends on the age and health of the person taking it, as well as the purpose for which the medication is taken. Incubation of magnesium L-threonate stimulates the activity of the signaling pathways of the extracellular signal-related protein kinase and the peroxisome proliferator-activated receptor gamma (PPARγ) by phosphorylation. Numerous research studies indicate that the beneficial components of magnesium L-threonate primarily target the brain.
If supporting brain performance is important to you, you may want to consider taking magnesium L-threonate. There is no exact time for magnesium L-threonate to start working because it varies from person to person. Regulation of structural and functional synapse density by L-threonate by modulating intraneuronal magnesium concentration has been observed. The preventive and therapeutic oral application of magnesium L-threonate blocks the regulation of tumor necrosis factor alpha in the hippocampus, which is essential for memory deficits. Magnesium should not be taken if you have kidney disease, as the kidneys normally remove magnesium from the body.
Magnesium l-threonate easily crosses the brain's protective filter, the blood-brain barrier, to reach the brain where it's needed.